Urticaria pigmentosa
Urticaria pigmentosa سڀ کان وڌيڪ عام قسم جي چمڙي جي ماسٽوسائيٽسس جو آهي. اها هڪ نادر بيماري آهي جيڪا چمڙي ۾ ماسٽ سيلز جي تمام گهڻي تعداد جي ڪري پيدا ٿئي ٿي جيڪا چمڙي تي خارش يا خارش پيدا ڪري ٿي. ڳاڙهي يا ناسي داغ اڪثر ڪري چمڙي تي نظر اچن ٿا، عام طور تي سينه، پيشاني ۽ پوئتي جي چوڌاري. اهي ماسٽ سيلز، جڏهن جلن ڪن ٿا (مثال طور چمڙي کي رڱڻ سان، گرميءَ جي نمائش)، تمام گهڻو هسٽامائن پيدا ڪن ٿا، هڪ الرجڪ رد عمل جو سبب بڻجن ٿا جن کي جلن واري علائقي ۾ hives مقامي ٿي وڃن ٿا، جن کي ڪڏهن ڪڏهن ”ڊيئر جي نشاني“ به چيو ويندو آهي.
☆ 2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
References
Mastocytosis هڪ حالت آهي جتي ماسٽ سيلز جي اضافي هوندي آهي، اڪثر ڪري جسم جي مختلف حصن جهڙوڪ چمڙي، هڏن جي ميرو، ۽ هاضمي سسٽم ۾ مليا آهن. ورلڊ هيلٿ آرگنائيزيشن (ڊبليو ايڇ او) جي مطابق، cutaneous mastocytosis کي ٽن مکيه قسمن ۾ ورهائي سگهجي ٿو. پهريون قسم (mastocytomas) اڪيلائي يا ڪجهه (≤3) زخمن تي مشتمل آهي. ٻئي قسم (urticaria pigmentosa) ۾ گھڻا زخم شامل آھن، عام طور تي 10 کان وڌيڪ کان 100 کان گھٽ تائين. آخري قسم سڄي چمڙي ۾ وسيع شموليت ڏيکاري ٿو. Urticaria pigmentosa ٻارن ۾ چمڙي جي ماسٽوسيٽوسس جو سڀ کان عام روپ آهي، پر اهو بالغن ۾ پڻ ٿي سگهي ٿو. اها عام طور تي هڪ بي ضرر حالت آهي جيڪا اڪثر نوجوانن جي دوران بهتر ٿي ويندي آهي. بالغ mastocytosis جي برعڪس، urticaria pigmentosa گهٽ ۾ گهٽ اندروني عضون کي متاثر ڪري ٿو. Urticaria pigmentosa جي هڪ خاص خصوصيت اها آهي ته ان جي چمڙي تي ننڍڙا، خارش، ڳاڙها-ڳاڙها، يا پيلا ناسي رنگ جا داغ يا زخم پيدا ٿيڻ جو رجحان آهي، جنهن کي عام طور تي hives طور سڃاتو وڃي ٿو. اهي اسپاٽ اڪثر ڪري ننڍپڻ ۾ ظاهر ٿيندا آهن ۽ سڄي زندگي گذاري سگهن ٿا.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
هڪ 6 سالن جي ڇوڪري اندر آئي جنهن ۾ ڪيترائي ڪارا رنگ جا داغ نظر آيا جيڪي پهريان هن جي چمڙي تي ظاهر ٿيا ۽ پوءِ گذريل ڇهن مهينن دوران هن جي منهن ۽ جسم تي پکڙجي ويا. هن محسوس ڪيو ته انهن کي اٿڻ، ڳاڙهي ٿيڻ، ۽ خارش محسوس ڪيو جڏهن دٻاء لاڳو ڪيو ويو. هن کي فلشنگ، الٽي، اسهرا، يا گھرگھڻ جو تجربو نه ڪيو ويو، ۽ هن جي ذاتي ۽ خانداني طبي تاريخن سان لاڳاپيل اشارو مهيا نه ڪيو. جانچ ڪرڻ تي، اسان کي هن جي ڳچيءَ، پيشاني، منهن ۽ ڳچيءَ تي ڪيترائي اونداهي داغ ڏٺا، ان سان گڏ هن جي سيني ۽ پٺيءَ تي ٿورڙا اونداهي دڳ نظر آيا. داغ کي ھلڪو رڱڻ سان 2 منٽن اندر سوڄ ۽ خارش ٿيڻ لڳي، پر 15-20 منٽن اندر علامتون ختم ٿي ويون (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
